2-Amino-4-methylpyridine → 2-Chloro-N-(4-methylpyridin-2-yl)acetamide

HRID 2192369Notes

Reaction equation

HRID 2192369 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 15332-Amino-4-methylpyridineHCID 6577Chloroacetyl chloride

Product 1

HCID 27767972-Chloro-N-(4-methylpyridin-2-yl)acetamideYield 74%

Procedure

The sub-titled compound (1.3 g, 74%, solid) was prepared by a similar procedure to that used to prepare Example 14f using 2-amino-4-methylpyridine in place of 2-amino-pyridine and adding the chloroacetyl chloride at room temperature rather than at 0° C.

Workup

  1. customto prepare Example 14f

Sources & evidence

ORD record
ord-4dc351a0bfee4dca8461d3430ce5058f
Source dataset
uspto-grants-2012_12
Patent number
US08329729B2

Reaction notes

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