反应详情

温度

65 °C

5-Isoquinolinecarbonitrile (2 g, 13 mmol; available from Fulcrum Scientific Product List), hydroxylamine.hydrochloride (7.21 g, 104 mmol) and sodium bicarbonate (10.9 g, 130 mmol), were added to a 0.5 L round bottomed flask containing ethanol (250 ml). The reaction mixture was heated at 65° C. for 3 hours and stirred for 12 hours. The cooled reaction mixture was evaporated to a smaller volume under reduced pressure and chromatographed over a 4×6 inch silica column eluting with ethanol to provide the title compound as a yellow solid (2.9 g).

1. customThe cooled reaction mixture
2. customwas evaporated to a smaller volume under reduced pressure
3. customchromatographed over a 4×6 inch silica column
4. washeluting with ethanol