Ethyl 4-piperidinecarboxylate → HCID 58149897, compound

HRID 2192472Notes

Reaction equation

HRID 2192472 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]3[N:16]=[C:15]([C:17]4[CH:22]=[CH:21][C:20]([O:23][CH:24]([CH3:26])[CH3:25])=[C:19]([Cl:27])[CH:18]=4)[O:14][N:13]=3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH:28]1[CH2:33][CH2:32][CH:31]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:30][CH2:29]1>C(O)CCC>[Cl:27][C:19]1[CH:18]=[C:17]([C:15]2[O:14][N:13]=[C:12]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:6]=3[CH:5]=[CH:4][N:3]=[C:2]4[N:28]3[CH2:33][CH2:32][CH:31]([C:34]([O:36][CH2:37][CH3:38])=[O:35])[CH2:30][CH2:29]3)[N:16]=2)[CH:22]=[CH:21][C:20]=1[O:23][CH:24]([CH3:25])[CH3:26]

Participants

4

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 58149900HCID 58149900, compound

Product 1

HCID 58149897HCID 58149897, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1-Chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline (D7; 50 mg, 0.125 mmol), ethyl 4-piperidinecarboxylate (available from Fluorochem; 0.077 ml, 0.500 mmol) and n-butanol (0.75 ml) were heated under microwave irradiation at 175° C. for 2 h. The reaction mixture was filtered to give the title compound as an off white solid (35 mg).

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-d4f68e2b9add475381b80cd6ea4b48f2
Source dataset
uspto-grants-2012_12
Patent number
US08329730B2

Reaction notes

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