Potassium Carbonate → HCID 58149929, compound

HRID 2192476Notes

Reaction equation

HRID 2192476 reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3]I.[Cl:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[OH:18])[C:11]([O:13][CH3:14])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:7][C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[O:18][CH2:3][C:2]([F:6])([F:5])[F:1])[C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 677091,1,1-Trifluoro-2-iodoethaneHCID 77580Methyl 3-chloro-4-hydroxybenzoate

Product 1

HCID 58149929HCID 58149929, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1,1,1-Trifluoro-2-iodoethane (1.162 ml, 11.80 mmol) was added to methyl 3-chloro-4-hydroxybenzoate (Alfa Aesar; 1.0 g, 5.36 mmol) and anhydrous potassium carbonate (0.889 g, 6.43 mmol) in N,N-dimethylformamide (DMF) (30.0 ml), and the mixture was heated under reflux with stirring under nitrogen for 16 h.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux

Sources & evidence

ORD record
ord-e5781d694bf94fda9d98ca947ac7896b
Source dataset
uspto-grants-2012_12
Patent number
US08329730B2

Reaction notes

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