p-Toluenesulfonic acid → HCID 67293727, compound

HRID 2192673Notes

Reaction equation

HRID 2192673 reaction equation
[NH2:1][CH:2]([C:16]([NH2:18])=[O:17])[C:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)=[O:4].[CH:19]([O-])([O-])OCC.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)C>[F:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][N:5]2[C:3]([OH:4])=[C:2]([C:16]([NH2:18])=[O:17])[N:1]=[CH:19]2)=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 53630039EthylorthoformateHCID 67293672HCID 67293672, compound

Product 1

HCID 67293727HCID 67293727, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reagents (1 eq. of 2-amino-N-[2-(4-fluorophenoxy)ethyl]malonamide 3 per 5 eq. of ethyl orthoformate) are placed in a 100 ml three-necked flask equipped with a condenser and a calcium chloride (CaCl2) guard tube, in refluxing absolute ethanol with a catalytic amount of para-toluenesulfonic acid (PTSA), for 2 hours 30 minutes.

Workup

  1. customequipped with a condenser and a calcium chloride (CaCl2) guard tube

Sources & evidence

ORD record
ord-1615ed821f2146178b6f8145a282c45d
Source dataset
uspto-grants-2012_12
Patent number
US08329738B2

Reaction notes

Loading…