反应详情

温度

150 °C

2-Chloro-6-methylnicotinic acid (1.72 g) and furfurylamine (1.94 g) were dissolved in 1-methylpyrrolidin-2-one (25 ml), and the mixture was stirred at 150° C. overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography. The fraction eluted with ethyl acetate-hexane (1:4-1:0) was concentrated under reduced pressure, and the precipitate was collected by filtration to give the object compound (838 mg) as a powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography
3. washThe fraction eluted with ethyl acetate-hexane (1:4-1:0)
4. concentrationwas concentrated under reduced pressure
5. filtrationthe precipitate was collected by filtration