反应详情

Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (1.26 g) was dissolved in DMF (10 ml), NaH (0.25 g) was added under ice-cooling, and the mixture was stirred at room temperature for 30 min. 1-Bromo-3-methoxypropane (0.83 g) was added to the reaction mixture under ice-cooling, and the mixture was stirred at 60° C. for 1 hr. The reaction mixture was concentrated, and the residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate-hexane (0:10-4:6) was concentrated under reduced pressure to give the object compound (1.1 g).

1. temperaturecooling
2. temperaturecooling
3. stirringthe mixture was stirred at 60° C. for 1 hr
4. concentrationThe reaction mixture was concentrated
5. washthe fraction eluted with ethyl acetate-hexane (0:10-4:6)
6. concentrationwas concentrated under reduced pressure