反应详情

To a solution of N-(5-acetylpyrazin-2-yl)-2,2-dimethylpropanamide (500 mg) in ethanol (10 mL) and THF (10 mL) was added sodium borohydride (86 mg) under ice-cooling, followed by stirring for 30 minutes under ice-cooling. To the reaction mixture was added 1 M hydrochloric acid under ice-cooling, followed by extraction with ethyl acetate. The organic layer was washed with saturated aqueous sodium bicarbonate and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated to obtain N-[5-(1-hydroxyethyl)pyrazin-2-yl]-2,2-dimethylpropanamide (525 mg) as a brown solid.

1. temperaturecooling
2. temperaturecooling
3. temperaturecooling
4. extractionfollowed by extraction with ethyl acetate
5. washThe organic layer was washed with saturated aqueous sodium bicarbonate and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated