反应详情

温度

60 °C

To a solution of N-(5-acetylpyrazin-2-yl)-2,2-dimethylpropanamide (300 mg) in methanol (10 mL) was added potassium carbonate (750 mg) at room temperature. It was stirred at 60° C. overnight. To the reaction mixture were added saturated aqueous sodium bicarbonate and saturated brine at room temperature, followed by extraction with a solvent (chloroform:isopropyl alcohol=4:1). The organic layer was dried over anhydrous magnesium sulfate and concentrated. The obtained solid was collected by filtration while washing with a solvent (hexane:diisopropyl ether=1:1), to obtain 1-(5-aminopyrazin-2-yl)ethanone (180 mg) as a pale yellow solid.

1. extractionfollowed by extraction with a solvent (chloroform:isopropyl alcohol=4:1)
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. concentrationconcentrated
4. filtrationThe obtained solid was collected by filtration
5. washwhile washing with a solvent (hexane:diisopropyl ether=1:1)