反应详情

温度

100 °C

To a stirred solution of 1-butoxy-9-fluoro-6-isopropylbenzo[c]-1,6-naphthyridine (33 mg, 0.11 mmol) in tetrahydrofuran (1.0 ml) was added 6N HCl (1.0 ml). The reaction mixture was stirred at 100° C. for 2 h, and then cooled to room temperature. The yellow precipitate was collected by vacuum filtration (rinsing the filter cake with THF) to afford 9-fluoro-6-isopropylbenzo[c]-1,6-naphthyridin-1(2H)-one (HCl salt). 1H NMR (500 MHz, DMSO-D6) δ 11.89 (br s, 1H), 9.76 (dd, 1H), 8.59 (dd, 1H), 7.63 (dt, 1H), 7.59 (t, 11-1), 6.79 (d, 1H), 6.33 (br peak, HCL/H2O), 4.09 (septet, 1H), 1.37 (d, 6H). LRMS (ESI) calc'd for (C15H13FN2O) [M+H]+, 257.1; found 257.1.

1. temperaturecooled to room temperature
2. filtrationThe yellow precipitate was collected by vacuum filtration (
3. washrinsing the filter cake with THF)