反应详情

A solution of 7.96 g of 1-benzhydrylazetidin-3-ylamine (33.41 mmol), 3.69 ml 3.4-difluoronitrobenzene (33.41 mmol) and 4.65 ml triethylamine (33.41 mmol)) in 50 ml ethyl acetate was stirred for 2 weeks at 60° C. The reaction was diluted with water and the product extracted with ethyl acetate. The organic layer was washed with water and brine, dried over MgSO4, filtered and evaporated.

1. extractionthe product extracted with ethyl acetate
2. washThe organic layer was washed with water and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customevaporated