Triethylamine → HCID 67274031, compound

HRID 2193548Notes

Reaction equation

HRID 2193548 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16]([NH2:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]1[CH:21]=[C:22]([N+:27]([O-:29])=[O:28])[CH:23]=[CH:24][C:25]=1F.C(N(CC)CC)C>C(OCC)(=O)C.O>[CH:1]([N:14]1[CH2:17][CH:16]([NH:18][C:25]2[CH:24]=[CH:23][C:22]([N+:27]([O-:29])=[O:28])=[CH:21][C:20]=2[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 57445463-Amino-1-(diphenylmethyl)azetidine

Product 1

HCID 67274031HCID 67274031, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 7.96 g of 1-benzhydrylazetidin-3-ylamine (33.41 mmol), 3.69 ml 3.4-difluoronitrobenzene (33.41 mmol) and 4.65 ml triethylamine (33.41 mmol)) in 50 ml ethyl acetate was stirred for 2 weeks at 60° C. The reaction was diluted with water and the product extracted with ethyl acetate. The organic layer was washed with water and brine, dried over MgSO4, filtered and evaporated.

Workup

  1. extractionthe product extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-5e00a6e8a54a42fe94848bba6eb0433e
Source dataset
uspto-grants-2012_12
Patent number
US08329908B2

Reaction notes

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