Water → HCID 67274376, compound

HRID 2193557Notes

Reaction equation

HRID 2193557 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:28][C@H:27]([CH2:29][N:30]=[N+]=[N-])[O:26][C:25]3=[O:33])=[CH:20][C:19]=2[F:34])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>C1COCC1>[CH2:1]([O:8][C:9]([N:11]1[CH2:12][CH2:13][CH:14]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:28][C@H:27]([CH2:29][NH2:30])[O:26][C:25]3=[O:33])=[CH:20][C:19]=2[F:34])[CH2:15][CH2:16]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 86597767HCID 86597767, compound

Product 1

HCID 67274376HCID 67274376, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2.51 g (5.35 mmol) 4-[4-{(5R)-5-azidomethyl2-oxo-oxazolidin-3-yl}-2-fluoro-phenylamino]-piperidine-1-carboxylic acid benzyl ester, 1.54 g (5.88 mmol) triphenylphosphine and 964 μl (53.5 mmol) water in 30 ml THF was stirred at 50° C. for 16 h.

Sources & evidence

ORD record
ord-0222cbf101624d9cba90bf15287f3e7a
Source dataset
uspto-grants-2012_12
Patent number
US08329908B2

Reaction notes

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