反应详情

温度

195 °C

To a solution of 123 (1.16 g, 4.18 mmol) in Ph2O (20 ml) was added 2-fluoro-4-nitrophenol (1.31 g, 8.37 mmol) and potassium carbonate (2.31 g, 16.72 mmol). The reaction mixture was heated to 195° C. for 18 hrs then cooled to room temperature. The residue was purified by column chromatography, eluents EtOAc/Hex (9/1 to 5/5), then MeOH/CH2Cl2 (98/2), to afford title compound 124 (1.47 g, 88% yield) as a yellow solid. MS (m/z): 399.0 (M+H).

1. temperaturethen cooled to room temperature
2. customThe residue was purified by column chromatography, eluents EtOAc/Hex (9/1 to 5/5)