反应详情

温度

195 °C

To a solution of 131 (3.37 g, 12.13 mmol) in Ph2O (40 ml) was added 2-fluoro-4-nitrophenol (3.81 g, 24.26 mmol) and potassium carbonate (6.70 g, 48.52 mmol). The reaction mixture was heated to 195° C. for 20 hrs then cooled to room temperature. The residue was purified by column chromatography, eluents EtOAc/Hex (9/1 to 5/5), then MeOH/DCM (98/2), to afford title compound 132 (4.13 g, 85% yield) as a yellow solid. MS (m/z): 399.0 (M+H).

1. temperaturethen cooled to room temperature
2. customThe residue was purified by column chromatography, eluents EtOAc/Hex (9/1 to 5/5)