2-Thiophenesulfonyl chloride → HCID 49801070, compound

HRID 2194019Notes

Reaction equation

HRID 2194019 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21](Cl)(=[O:23])=[O:22].[F:25][C:26]([F:36])([F:35])[O:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>>[S:16]1[CH:20]=[CH:19][CH:18]=[C:17]1[S:21]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:32]([C:31]3[CH:33]=[CH:34][C:28]([O:27][C:26]([F:25])([F:35])[F:36])=[CH:29][CH:30]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:23])=[O:22]

Participants

4

Reactant 3

HCID 855182-Thiophenesulfonyl chlorideHCID 6008484-(Trifluoromethoxy)anilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49801070HCID 49801070, compound

Procedure

Light yellow solid. MS (ESI): 461.08 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), thiophene-2-sulfonyl chloride and 4-(trifluoromethoxy)aniline.

Sources & evidence

ORD record
ord-5c53331d58024f5b943f01f13da05a70
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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