Piperidine → HCID 59577889, compound

HRID 2194235Notes

Reaction equation

[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[C:10]2=[O:19])=[CH:5][CH:4]=1)[CH3:2].O=C(Cl)[O:22][C:23](Cl)(Cl)Cl.[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:13][CH2:12][C:11]3([CH2:18][CH2:17][N:16]([C:23]([N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[O:22])[CH2:15][CH2:14]3)[C:10]2=[O:19])=[CH:7][CH:8]=1)[CH3:2]

Participants

Reactant 3

HCID 8082Piperidine

HCID 10426Diphosgene

HCID 58287273HCID 58287273, compound

Product 1

HCID 59577889HCID 59577889, compound

Procedure

This material was prepared in analogy to example 251 step B) from 2-(4-Ethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one, diphosgene and piperidine. MS (ESI): 370.3 (MH+).

Sources & evidence

ORD record: ord-026deb97fd0f4f2e81710c9f26b3c70d
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329904B2

Reaction notes

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