反应详情

18 mg of sodium hydride (60%) was added to N,N-dimethylformamide (5 mL) solution of 107 mg of ethyl 2-(9H-carbazole-4-yloxy)acetate, and stirred at room temperature for 20 minutes. Thereafter, 144 mg of 4-((4-(chloromethyl)-2-methoxyphenoxy)methyl)-5-methyl-2-phenyloxazole was added thereto, and stirred at room temperature for 1 hour. The reaction mixture was poured into water, and extracted twice with ethyl acetate. The combined extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, the residue was crystallized from methanol, isolated by filtration, and washed with methanol. The residue was dried under reduced pressure, and 107 mg of the subject compound was prepared as white crystal.

1. stirringstirred at room temperature for 1 hour
2. extractionextracted twice with ethyl acetate
3. extractionThe combined extract
4. washwas washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationAfter filtration
7. concentrationthe filtrate was concentrated in vacuo
8. customthe residue was crystallized from methanol
9. customisolated by filtration
10. washwashed with methanol
11. dry with materialThe residue was dried under reduced pressure, and 107 mg of the subject compound
12. customwas prepared as white crystal