Sodium Hydroxide → HCID 59571714, compound

HRID 2194316Notes

Reaction equation

HRID 2194316 reaction equation
[OH-].[Na+:2].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][C:35]=1[O:36][CH2:37][C:38]1[N:39]=[C:40]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[O:41][C:42]=1[CH3:43])[CH2:8][N:9]1[C:21]2[CH:20]=[CH:19][CH:18]=[C:17]([O:22][CH:23]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:24]([OH:26])=[O:25])[C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2>CC(O)C>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:33]=[CH:34][C:35]=1[O:36][CH2:37][C:38]1[N:39]=[C:40]([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[O:41][C:42]=1[CH3:43])[CH2:8][N:9]1[C:21]2[CH:20]=[CH:19][CH:18]=[C:17]([O:22][CH:23]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:24]([O-:26])=[O:25])[C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11700118HCID 11700118, compound

Product 1

HCID 59571714HCID 59571714, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.5 N sodium hydroxide solution (3.1 mL) was added to the solution of 980 mg of (+)-2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-phenylacetic acid in 2-propanol (30 mL). 2-propanol was removed under reduced pressure, the residue was collected by filtration with a small amount of 2-propanol, and 850 mg of the subject compound was prepared as pale brown powder. Optical purity>99% ee (HPLC)

Workup

  1. custom2-propanol was removed under reduced pressure
  2. filtrationthe residue was collected by filtration with a small amount of 2-propanol, and 850 mg of the subject compound
  3. customwas prepared as pale brown powder

Sources & evidence

ORD record
ord-35e6adbcea7743b498db2659f687a9f6
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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