HCID 11714078, compound → HCID 59571734, compound

HRID 2194318Notes

Reaction equation

HRID 2194318 reaction equation
C(C(CCCC)C([O-])=O)C.[Na+:11].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:39]=[CH:40][C:41]=1[O:42][CH2:43][C:44]1[N:45]=[C:46]([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[O:47][C:48]=1[CH3:49])[CH2:17][N:18]1[C:30]2[CH:29]=[CH:28][CH:27]=[C:26]([O:31][CH2:32][CH2:33][CH:34]([CH3:38])[C:35]([OH:37])=[O:36])[C:25]=2[C:24]2[C:19]1=[CH:20][CH:21]=[CH:22][CH:23]=2>C(OCC)(=O)C>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:39]=[CH:40][C:41]=1[O:42][CH2:43][C:44]1[N:45]=[C:46]([C:50]2[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=2)[O:47][C:48]=1[CH3:49])[CH2:17][N:18]1[C:30]2[CH:29]=[CH:28][CH:27]=[C:26]([O:31][CH2:32][CH2:33][CH:34]([CH3:38])[C:35]([O-:37])=[O:36])[C:25]=2[C:24]2[C:19]1=[CH:20][CH:21]=[CH:22][CH:23]=2.[Na+:11]

Participants

4

Reactant 2

HCID 11714078HCID 11714078, compoundHCID 23672331Sodium 2-ethylhexanoate

Product 1

HCID 59571734HCID 59571734, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Sodium 2-ethylhexanoate (479 mg) was added to the solution of 1.5 g of 4-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}-2-methyl-butyric acid prepared by the example 52(b) in ethyl acetate (15 mL) at room temperature. After stirring at room temperature for 30 minutes, the precipitate was isolated by filtration, washed with ethanol, dried under reduced pressure, and 1.49 g of the subject compound was prepared as white powder. Optical purity>99% ee (HPLC)

Workup

  1. customthe precipitate was isolated by filtration
  2. washwashed with ethanol
  3. dry with materialdried under reduced pressure, and 1.49 g of the subject compound
  4. customwas prepared as white powder

Sources & evidence

ORD record
ord-3b26ac7866264b9d9209781fad7a6126
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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