2-Bromoethyl methyl ether → 4-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-(2-methoxy-ethyl)-1H-pyridin-2-one

HRID 2194427Notes

Reaction equation

HRID 2194427 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:6][CH:7]=1.Br[CH2:25][CH2:26][O:27][CH3:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:23])[N:13]([C:16]3[CH:21]=[CH:20][N:19]([CH2:25][CH2:26][O:27][CH3:28])[C:18](=[O:22])[CH:17]=3)[C:14]=2[CH3:15])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 498725784-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1H-pyridin-2-one

Product 1

HCID 498726704-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1-(2-methoxy-ethyl)-1H-pyridin-2-one

Procedure

The title compound, white crystalline solid, MS: m/e=382.3, 384.1 (M+H+), was prepared in accordance with the general method of example 3 from 4-[4-(3-chloro-phenylethynyl)-2,5-dimethyl-imidazol-1-yl]-1H-pyridin-2-one and 2-bromoethyl-methylether.

Sources & evidence

ORD record
ord-d80d3cfd1a534c4ebd249cbd10c65569
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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