Trifluoroacetic acid → HCID 178461301, compound

HRID 2194567Notes

Reaction equation

HRID 2194567 reaction equation
[CH3:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]2[N:14]=[C:13]([O:15][CH2:16][C@@H:17]3[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]3)[C:12]([C:29]3[CH:34]=[CH:33][C:32]([N:35]4[CH2:40][CH2:39][O:38][CH2:37][CH2:36]4)=[CH:31][CH:30]=3)=[CH:11][N:10]=2)[CH2:4][CH2:3]1.C(O)(C(F)(F)F)=O>>[NH:19]1[CH2:20][CH2:21][C@@H:17]([CH2:16][O:15][C:13]2[C:12]([C:29]3[CH:30]=[CH:31][C:32]([N:35]4[CH2:36][CH2:37][O:38][CH2:39][CH2:40]4)=[CH:33][CH:34]=3)=[CH:11][N:10]=[C:9]([NH:8][C@H:5]3[CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:7][CH2:6]3)[N:14]=2)[CH2:18]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452028HCID 178452028, compound

Product 1

HCID 178461301HCID 178461301, compound

Procedure

Using the procedure of Example 1 Step 4, (R)-tert-butyl 3-((2-(cis-4-methylcyclohexylamino)-5-(4-morpholinophenyl)pyrimidin-4-yloxy)methyl)pyrrolidine-1-carboxylate was deprotected by TFA to provide the title compound at quantitative yield. MS (ESI) m/z: Found: 452.3 (M+1). Calc. 451.3 (M+).

Sources & evidence

ORD record
ord-d78ae05e230e43abbd78c5abfb11c327
Source dataset
uspto-grants-2012_12
Patent number
US08334292B1

Reaction notes

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