Potassium Carbonate → HCID 86631605, compound

HRID 2194690Notes

Reaction equation

HRID 2194690 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][C:3]=1[C:9]1[C:10]([F:15])=[N:11][CH:12]=[CH:13][CH:14]=1.[SH:16][C:17]1[S:18][CH:19]=[CH:20][N:21]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:15][C:10]1[C:9]([C:3]2[CH:4]=[C:5]([CH:7]=[O:8])[S:6][C:2]=2[S:16][C:17]2[S:18][CH:19]=[CH:20][N:21]=2)=[CH:14][CH:13]=[CH:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 86631600HCID 86631600, compoundHCID 178527881HCID 178527881, compound

Product 1

HCID 86631605HCID 86631605, compoundYield 100.1%

Procedure

With 5-bromo-4-(2-fluoropyridin-3-yl)thiophene-2-carbaldehyde (250 mg) as a starting material, and using 2-mercaptothiazole (134 mg) and potassium carbonate (193 mg), an operation similar to that of Reference Example 1 was performed to give the title compound as a white powder (yield 282 mg, yield 100%).

Sources & evidence

ORD record
ord-d5e5914ad6684a4cab11bfbaa55c5a7a
Source dataset
uspto-grants-2012_12
Patent number
US08334301B2

Reaction notes

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