Thiophenol → HCID 86644412, compound

HRID 2194692Notes

Reaction equation

HRID 2194692 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][C:3]=1[C:9]1[C:10]([F:15])=[N:11][CH:12]=[CH:13][CH:14]=1.[C:16]1([SH:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:15][C:10]1[C:9]([C:3]2[CH:4]=[C:5]([CH:7]=[O:8])[S:6][C:2]=2[S:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:14][CH:13]=[CH:12][N:11]=1

Participants

4

Reactant 3

HCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 86631600HCID 86631600, compound

Product 1

HCID 86644412HCID 86644412, compoundYield 99%

Procedure

With 5-bromo-4-(2-fluoropyridin-3-yl)thiophene-2-carbaldehyde (2.86 g) as a starting material, and using thiophenol (1.33 mL) and potassium carbonate (2.21 g), an operation similar to that of Reference Example 1 was performed to give the title compound as a pale-yellow oil (yield 3.11 g, yield 99%).

Sources & evidence

ORD record
ord-accf0c1595f143e48979bbbceb051ef6
Source dataset
uspto-grants-2012_12
Patent number
US08334301B2

Reaction notes

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