Potassium Carbonate → HCID 58203528, compound

HRID 2194772Notes

Reaction equation

HRID 2194772 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:34]=[C:35]([CH3:37])[CH:36]=1)[C:6]([C:8]1[N:13]([CH2:14][CH2:15][O:16]C(=O)C)[C:12](=[O:20])[N:11]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)[C:10](=[O:30])[C:9]=1[CH:31]([CH3:33])[CH3:32])=[O:7])#[N:2].C(=O)([O-])[O-].[K+].[K+]>CO>[OH:16][CH2:15][CH2:14][N:13]1[C:8]([C:6]([C:5]2[CH:4]=[C:3]([CH:36]=[C:35]([CH3:37])[CH:34]=2)[C:1]#[N:2])=[O:7])=[C:9]([CH:31]([CH3:33])[CH3:32])[C:10](=[O:30])[N:11]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=2)[C:12]1=[O:20]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58203438HCID 58203438, compound

Product 1

HCID 58203528HCID 58203528, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Acetic acid 2-[6-(3-cyano-5-methyl-benzoyl)-5-isopropyl-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-ethyl ester (88 mg, 0.175 mmol, 1.2 eq.) was dissolved in 1.5 mL MeOH. Potassium carbonate (48 mg, 0.349 mmol, 2 eq.) was added and the reaction mixture was stirred at room temperature for 20 minutes. The reaction mixture was concentrated down and purified (silica gel, 0-10% MeOH/DCM) to give a white powder (76 mg, 94%). LC-MS shows 462.1 (M+1).

Workup

  1. concentrationThe reaction mixture was concentrated down
  2. custompurified (silica gel, 0-10% MeOH/DCM)

Sources & evidence

ORD record
ord-4112c0e8c03049aaa8efae5215da6cf4
Source dataset
uspto-grants-2012_12
Patent number
US08334295B2

Reaction notes

Loading…