Indole → HCID 58203437, compound

HRID 2194782Notes

Reaction equation

Cl[C:2]1[CH:3]=[C:4](C#N)[C:5]2[CH:6]=[CH:7][N:8]([C:11]3[N:12]([CH2:22][CH3:23])[C:13](=[O:21])[NH:14][C:15](=[O:20])[C:16]=3[CH:17]([CH3:19])[CH3:18])[C:9]=2[CH:10]=1.N1C2C(=CC=CC=2)C=C1>>[CH2:22]([N:12]1[C:11]([N:8]2[C:9]3[C:5](=[CH:4][CH:3]=[CH:2][CH:10]=3)[CH:6]=[CH:7]2)=[C:16]([CH:17]([CH3:18])[CH3:19])[C:15](=[O:20])[NH:14][C:13]1=[O:21])[CH3:23]

Participants

Reactant 2

HCID 798Indole

HCID 67050527HCID 67050527, compound

Product 1

HCID 58203437HCID 58203437, compound

Procedure

This compound was made by a procedure similar to that used to prepare 6-chloro-1-(3-ethyl-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-1H-indole-4-carbonitrile (90), except that 1H-indole was used instead of 6-chloro-1H-indole-4-carbonitrile. LC-MS shows 298.2 (M+1). 1H NMR (300 MHz, CDCl3): δ 8.32 (br, 1H), 7.72 (d, 1H), 7.25 (m, 2H), 7.19 (m, 1H), 6.80 (m, 1H), 3.50 (m, 1H), 3.18 (m, 1H), 1.97 (m, 1H), 1.17 (dd, 6H), 1.03 (t, 3H).

Sources & evidence

ORD record: ord-868a81d71adc4c40887c8e5be4bc733f
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334295B2

Reaction notes

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