反应详情

Heat a mixture of 4-(4-fluoro-phenyl)-6-(2-(R)-methyl-piperazin-1-yl)-2-(2-(R)-methyl-pyrrolidin-1-yl)-pyrimidine (400 mg, 1.13 mmol), 2,5-dibromo-3-methyl-pyridine (367 mg, 1.46 mmol), and DIEA (218 mg, 1.69 mmol) in DMA at 135° C. for 96 h. Dilute with water, extract with EtOAc, and wash with brine. Dry the organic layer (Na2SO4) and concentrate under reduced pressure. Purify the residue by flash column chromatography eluting with EtOAc-Hexanes (1:10) to afford the title compound as a white solid.

1. temperatureHeat
2. extractionextract with EtOAc
3. washwash with brine
4. dry with materialDry the organic layer (Na2SO4)
5. concentrationconcentrate under reduced pressure
6. customPurify the residue by flash column chromatography
7. washeluting with EtOAc-Hexanes (1:10)