反应详情

温度

110 °C

A solution of florfenicol (0.090 g, 0.25 mmol) in acetic acid (3.0 mL) was treated with sulfuric acid (10%, 15 mL) and heated to 110° C. for 12 h. The reaction mixture was cooled to room temperature, treated with 10 M aqueous sodium hydroxide to adjust the pH to 14, extracted with dichloromethane (3×30 mL), dried (Na2SO4), and evaporated to provide florfenicol amine 60 (65 mg, 0.25 mmol) as a yellow oil.

1. temperatureThe reaction mixture was cooled to room temperature
2. extractionextracted with dichloromethane (3×30 mL)
3. dry with materialdried (Na2SO4)
4. customevaporated