反应详情

A mixture of 6-methoxyquinoline (69 μL, 0.5 mmol), ammonium formate (0.32 g, 5.0 mmol), and 10% Pd/C (0.05 g) in anhydrous MeOH (5 mL) was microwaved for 900 s at 100° C. The mixture was filtered and 2M HCl in Et2O (1.5 mL) was added. The product was redissolved in H20/DCM and the aqueous layer basified with 0.1M aq. NaOH (pH 8). After extracting three times with DCM, the organic layer was concentrated to give the product in 89% yield. The product was used without further purification. LC/MS (10-99%) M/Z: M+1 obs=164.0; tR=0.40 min.

1. customwas microwaved for 900 s at 100° C
2. filtrationThe mixture was filtered
3. addition2M HCl in Et2O (1.5 mL) was added
4. dissolutionThe product was redissolved in H20/DCM
5. extractionAfter extracting three times with DCM
6. concentrationthe organic layer was concentrated
7. customto give the product in 89% yield
8. customThe product was used without further purification