Hydrochloric Acid → HCID 68766864, compound

HRID 2196432Notes

Reaction equation

HRID 2196432 reaction equation
[ClH:1].C(OC([N:7]1[CH:12]2[CH2:13][CH2:14][CH2:15][CH:8]1[CH2:9][CH:10]([CH2:16][C:17]([OH:19])=[O:18])[CH2:11]2)=O)C>>[ClH:1].[CH:8]12[NH:7][CH:12]([CH2:13][CH2:14][CH2:15]1)[CH2:11][CH:10]([CH2:16][C:17]([OH:19])=[O:18])[CH2:9]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59575628HCID 59575628, compound

Product 1

HCID 68766864HCID 68766864, compoundYield 95%

Procedure

Concentrated HCl (36%, 73.5 ml) was added to [9-(ethoxy carbonyl)-9-azabicyclo[3.3.1]-non-3-yl]-acetic acid (4.9 g, 19.2 m mol) under stirring at room temperature. The reaction mixture was heated at 100° C. for 8 hours and progress of reaction was monitored by mass spectroscopy. After the completion of reaction, the reaction mixture was evaporated to dryness under reduced pressure and traces of water was removed by evaporating with dichloromethane (3×50 ml) the crude product was dried under high vacuum to yield the title compound (4.01 g, 95%) and subjected to further reaction without purification

Workup

  1. temperatureThe reaction mixture was heated at 100° C. for 8 hours
  2. customprogress of reaction
  3. customAfter the completion of reaction
  4. customthe reaction mixture was evaporated to dryness under reduced pressure and traces of water
  5. customwas removed
  6. customby evaporating with dichloromethane (3×50 ml) the crude product
  7. customwas dried under high vacuum

Sources & evidence

ORD record
ord-e3ebf20d08a741859c1df6a90243e0dd
Source dataset
uspto-grants-2012_12
Patent number
US08338450B2

Reaction notes

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