Hydrochloric Acid → HCID 44231021, compound

HRID 2196448Notes

Reaction equation

HRID 2196448 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[N:11]=[C:12]4[CH:17]=[CH:16][C:15]([C:18]5[CH:19]=[C:20]([CH2:24][OH:25])[CH:21]=[CH:22][CH:23]=5)=[CH:14][N:13]4[CH:26]=3)[CH:8]=2)[CH:3]=[CH:2]1.[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]3[N:11]=[C:12]4[CH:17]=[CH:16][C:15]([C:18]5[CH:19]=[C:20]([CH2:24][OH:25])[CH:21]=[CH:22][CH:23]=5)=[CH:14][N:13]4[CH:26]=3)[CH:8]=2)[CH:3]=[CH:2]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 44231022HCID 44231022, compound

Product 1

HCID 44231021HCID 44231021, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

110 mg of {3-[2-(1H-indol-6-yl)imidazo[1,2-a]pyridin-6-yl]phenyl}methanol are suspended in dichloromethane and methanol; 3.2 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether, and the precipitate is recovered by filtration and oven-dried under reduced pressure.

Workup

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-fe01cf55f4134c8b910a1839f8eef57f
Source dataset
uspto-grants-2012_12
Patent number
US08338451B2

Reaction notes

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