Hydrochloric Acid → [3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

HRID 2196455Notes

Reaction equation

HRID 2196455 reaction equation
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.[ClH:24]>ClCCl.CO.C(O)(C)C>[ClH:24].[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 44231018[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol

Product 1

HCID 44231017[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

140 mg of [3-(3-methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol are suspended in dichloromethane and methanol; 3.2 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether, and the precipitate is recovered by filtration and oven-dried under reduced pressure. 150 mg of compound are obtained.

Workup

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. customoven-dried under reduced pressure

Sources & evidence

ORD record
ord-15135a70d3f345c7aa492b4069a6eab4
Source dataset
uspto-grants-2012_12
Patent number
US08338451B2

Reaction notes

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