Tetrahydrofuran → HCID 69300880, compound

HRID 2196519Notes

Reaction equation

HRID 2196519 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]([C:11]2[S:12][CH:13]=[C:14]([C:16]([O:18]CC)=O)[N:15]=2)[N:9]=[C:8]([C:21]([F:24])([F:23])[F:22])[CH:7]=1.[OH-].[NH4+:26].C1COCC1>CO>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]([C:11]2[S:12][CH:13]=[C:14]([C:16]([NH2:26])=[O:18])[N:15]=2)[N:9]=[C:8]([C:21]([F:23])([F:22])[F:24])[CH:7]=1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14923Ammonium HydroxideHCID 4873430HCID 4873430, compound

Product 1

HCID 69300880HCID 69300880, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a stirred suspension of 29 (345 mg, 0.966 mmol) in methanol (1.5 mL) at room temperature was added ammonium hydroxide (1.5 mL, 38.5 mmol). The resulting solution was allowed to stir for 1 h at 50° C. THF (1 mL) was then added and the mixture was stirred for 16 h at 50° C. Solvent was evaporated, and the crude product 30 was isolated. LRMS (ESI): calc. 328.0; found 329.0 (MH)+.

Workup

  1. stirringthe mixture was stirred for 16 h at 50° C
  2. customSolvent was evaporated

Sources & evidence

ORD record
ord-eba29b7a1d994ce48ac6d673b1e9e1bf
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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