Trifluoroacetic acid → HCID 59843310, compound

HRID 2196544Notes

Reaction equation

HRID 2196544 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:10]([CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[N:9]=[C:8]([C:24]([F:27])([F:26])[F:25])[CH:7]=1)=[O:5])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH:14]1[CH2:15][CH2:16][CH:11]([N:10]2[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:7][C:8]([C:24]([F:25])([F:26])[F:27])=[N:9]2)[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59843183HCID 59843183, compound

Product 1

HCID 59843310HCID 59843310, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
21 °C

Procedure

To a stirred solution of 93 (1.014, 2.59 mmol) in CH2Cl2 (13 ml) was added TFA (3 ml, 38.9 mmol). The resulting solution was allowed to stir at 21° C. for 2 h. After the usual work-up, crude 94 was obtained as colorless oil. LRMS (ESI): calc. 291.3; found 292.2 (MH)+.

Workup

  1. customAfter the usual work-up, crude 94 was obtained as colorless oil

Sources & evidence

ORD record
ord-4136ac8ff3e7410e8896fbc406eb09ad
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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