Trifluoroacetic acid → HCID 178489348, compound

HRID 2196572Notes

Reaction equation

HRID 2196572 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[NH:13][C:12]2[C:14]([C:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH:23]=3)=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:11]=2[N:10]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[NH:13][C:12]2[C:14]([C:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH:23]=3)=[CH:15][C:16]([C:18]([F:21])([F:19])[F:20])=[CH:17][C:11]=2[N:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178489349HCID 178489349, compound

Product 1

HCID 178489348HCID 178489348, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 177 (47 mg, 0.099 mmol) was stirred in a solution of DCM (0.8 mL) and TFA (0.200 mL) for 1 hour. After the usual work-up 2-(2-methoxyphenyl)-7-(1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazole was obtained (34 mg, 0.091 mmol, 92% yield). LRMS (ESI): (calc.) 373.4 (found) 374.1 (MH)+

Sources & evidence

ORD record
ord-2365c1782c6b447f9485470296440696
Source dataset
uspto-grants-2012_12
Patent number
US08338437B2

Reaction notes

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