Triphenylphosphine → [(4'-Chloro-1,1'-biphenyl-2-yl)methyl](triphenyl)phosphonium bromide

HRID 2196764Notes

Reaction equation

HRID 2196764 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1.[C:16]1([P:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C(C)=CC=CC=1>[Br-:1].[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[CH2:2][P+:22]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 582376872-(Bromomethyl)-4'-chlorobiphenyl

Product 1

HCID 87286191[(4'-Chloro-1,1'-biphenyl-2-yl)methyl](triphenyl)phosphonium bromide

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of EXAMPLE 37B (8.05 g) and triphenylphosphine (7.5 g) in xylene (100 mL) was heated to 110° C. for one hour. The reaction was cooled and filtered, and the solid washed with toluene, and vacuum-dried to give the title compound.

Workup

  1. temperatureThe reaction was cooled
  2. filtrationfiltered
  3. washthe solid washed with toluene
  4. customvacuum-dried

Sources & evidence

ORD record
ord-92bb810213df4c32b0d109cd30344ffb
Source dataset
uspto-grants-2012_12
Patent number
US08338466B2

Reaction notes

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