Sodium hydride → HCID 86630977, compound

HRID 2196975Notes

Reaction equation

HRID 2196975 reaction equation
[H-].[Na+].[CH:3]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[NH:19][CH:18]=[C:17]([CH:20]=[O:21])[CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([S:28](Cl)(=[O:30])=[O:29])[CH:23]=1>O1CCCC1>[CH:3]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:19]([S:28]([C:24]4[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=4)(=[O:30])=[O:29])[CH:18]=[C:17]([CH:20]=[O:21])[CH:16]=3)=[CH:11][CH:10]=2)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 3164136Pyridine-3-sulfonyl chlorideHCID 86630972HCID 86630972, compound

Product 1

HCID 86630977HCID 86630977, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydride (60% in oil, 68 mg) was added to a solution of 5-(4-cyclohexylphenyl)-1H-pyrrole-3-carbaldehyde (0.17 g) in tetrahydrofuran (12 mL) at room temperature. The mixture was stirred for 20 min, 3-pyridinesulfonyl chloride (0.19 g) was added, and the mixture was stirred at room temperature for 3 hr. The reaction mixture was poured into ice water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate=3:2→2:1) to give the title compound as crystals (yield 0.26 g, 97%).

Workup

  1. stirringthe mixture was stirred at room temperature for 3 hr
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (eluent:hexane-ethyl acetate=3:2→2:1)

Sources & evidence

ORD record
ord-1d00deaf7be64a07988650df481ffb56
Source dataset
uspto-grants-2012_12
Patent number
US08338461B2

Reaction notes

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