反应详情

温度

100 °C

A solution of the product from Example 2b (348 mg, 1.52 mmol) and NH2OH HCl (530 mg, 7.62 mmol) in 4 mL of EtOH/1.5 mL water. Heated at 100° C. for 16 h, cooled to room temperature and extracted with CH2Cl2. Dried over MgSO4 filtered and concentrated under vacuum giving the title compound as an amber oil (223 mg, 100%).

1. temperaturecooled to room temperature
2. extractionextracted with CH2Cl2
3. dry with materialDried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated under vacuum