Iodoethane → 2-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

HRID 2197738Notes

Reaction equation

[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH2:15](I)[CH2:16][CH3:17].C(I)C>>[CH2:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([N:3]2[C:2]([CH3:1])=[CH:6][CH:5]=[C:4]2[CH3:7])[N:9]=1)[CH2:15][CH2:16][CH3:17]

Participants

Reactant 3

HCID 6340Iodoethane

HCID 336431-Iodopropane

HCID 7931562-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-methylpyridine

Product 1

HCID 133983052-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridineYield 64.4%

Procedure

The product from Example 2a 1.0 g, 5.37 mmol) was reacted with propyl iodide 0.55 mL, 5.64 mmol) in place of ethyl iodide following the procedure from Example 2b to give the title compound (790 mg, 64%).

Sources & evidence

ORD record: ord-bfa0ec23f2f34a69a919898f169d5ee6
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08338605B2

Reaction notes

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