Methylamine → HCID 68460694, compound

HRID 2197893Notes

Reaction equation

HRID 2197893 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][NH2:22]>C1COCC1>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([NH:22][CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

Product 1

HCID 68460694HCID 68460694, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from Example 126c (225 mg, 0.72 mmol) was reacted with methylamine (1.0 mL, 2.0 mmol) in THF (20 mL) at room temperature. The THF was removed under reduced pressure. The crude residue was purified by flash chromatography eluting with hexanes/ethyl acetate (30:70) to give the title compound (110 mg, 50%).

Workup

  1. customThe THF was removed under reduced pressure
  2. customThe crude residue was purified by flash chromatography
  3. washeluting with hexanes/ethyl acetate (30:70)

Sources & evidence

ORD record
ord-a53d16fe40e8418aabbefd9f1b916d5a
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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