Potassium Carbonate → HCID 9112126, compound

HRID 2197962Notes

Reaction equation

HRID 2197962 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C([O-])([O-])=O.[K+].[K+].[CH3:18][O:19][C:20](=[O:28])[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([OH:27])[CH:22]=1>CN(C=O)C.O>[CH3:18][O:19][C:20](=[O:28])[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=2[N+:9]([O-:11])=[O:10])[CH:22]=1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 88068Methyl 3-HydroxybenzoateHCID 27949042-Bromo-5-chloronitrobenzene

Product 1

HCID 9112126HCID 9112126, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

1-Bromo-4-chloro-2-nitro-benzene (7.00 g, 29.60 mmol) was dissolved in DMF to which K2CO3 (5.11 g, 37.01 mmol) and 3-Hydroxy-benzoic acid methyl ester (4.95 g, 32.57 mmol) were added. The reaction mixture was then heated to 100° C. for 2 h the reaction mixture was cooled to room temperature and diluted with water and extracted with ethyl acetate. Solvent dried over Na2SO4, filtered and concentrated under vacuum giving the title compound. (7.2 g, 79%)

Workup

  1. additionwere added
  2. temperaturewas cooled to room temperature
  3. extractionextracted with ethyl acetate
  4. dry with materialSolvent dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-4a0f90a2caca4426b2f4aea9ae491ff6
Source dataset
uspto-grants-2012_12
Patent number
US08338605B2

Reaction notes

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