Hydrochloric Acid → HCID 66727315, compound

HRID 2198187Notes

Reaction equation

HRID 2198187 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH:10]S(C(C)(C)C)=O)[CH2:8][CH3:9])[O:4][N:3]=1.[ClH:17].O1CCOCC1>CO>[ClH:17].[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH2:10])[CH2:8][CH3:9])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727467HCID 66727467, compound

Product 1

HCID 66727315HCID 66727315, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(3-bromo-isoxazol-5-yl)-propyl]-amide (17.5 mg, 0.0566 mmol) in MeOH (1 mL) was added a 4 M solution of HCl in dioxane (0.70 mL, 0.28 mmol) dropwise. After 2.5 hours, the mixture was concentrated in vacuo to afford the title compound which was used with out purification. MS m/z 188.24 (M-53), 190.20 (M+2-53).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-0396d21d129f481facac42301a2f53fb
Source dataset
uspto-grants-2012_12
Patent number
US08338610B2

Reaction notes

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