Formaldehyde → HCID 44242436, compound

HRID 2198323Notes

Reaction equation

HRID 2198323 reaction equation
Cl.ClC1C=CC(NN)=CC=1.BrCCCC1C=CC(F)=CC=1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]([CH2:31][CH2:32][CH2:33][C:34]2[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=2)N)=[CH:25][CH:24]=1.C(OC(OCC)CCCNC)C.ClC1C=C2[C:60](=CC=1)[N:59]([CH2:63][CH2:64][CH2:65][C:66]1[CH:71]=CC(F)=CC=1)C=C2CCNC.C=O.C(O)(C(F)(F)F)=O>C(#N)C.C(N(CC)CC)C>[Cl:22][C:23]1[CH:28]=[C:27]2[C:26](=[CH:25][CH:24]=1)[N:29]([CH2:31][CH2:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=1)[C:66]1[CH2:71][N:59]([CH3:60])[CH2:63][CH2:64][C:65]2=1

Participants

10

Reactant 7

HCID 712FormaldehydeHCID 6422Trifluoroacetic acidHCID 71600Hydrazine, (4-chlorophenyl)-, hydrochloride (1:1)HCID 139945474,4-Diethoxy-N-methylbutan-1-amineHCID 147371331-(3-Bromopropyl)-4-fluorobenzeneHCID 66911699HCID 66911699, compoundHCID 66911802HCID 66911802, compound

Product 1

HCID 44242436HCID 44242436, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8471TriethylamineSolvent

Procedure

The title compound is prepared by following General Methods 1, 3 and 4 using 4-chlorophenylhydrazine hydrochloride, 1-(3-bromopropyl)-4-fluorobenzene, and triethylamine (General Method 1), 1-(4-chlorophenyl)-1-(3-(4-fluorophenyl)propyl)hydrazine and 4,4-diethoxy-N-methylbutan-1-amine (General Method 3) and 2-(5-chloro-1-(3-(4-fluorophenyl)propyl)-1H-indol-3-yl)-N-methylethanamine, formaldehyde and TFA in acetonitrile (General Method 4).

Sources & evidence

ORD record
ord-b484ed932dae425ea8074d60fa1e86fe
Source dataset
uspto-grants-2012_12
Patent number
US08338447B2

Reaction notes

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