反应详情

21-Chloro-17α-hydroxy-20-methoxypregna-4,9(11),20-trien-3-one (IX, Example 4, 1.0 g), THF (4 ml), acetone (4.9 ml), and methanol (1.4 ml) are mixed. Aqueous hydrochloric acid (6 N, 0.44 ml) is added and the resulting slurry heated at 40° for 1.5 hours. The mixture is cooled to 20°-25° and diluted with hexane (3 ml). The solids are isolated by filtration and washed with hexane/ethyl acetate (85/15, 13 ml) to give the title compound.

1. temperaturethe resulting slurry heated at 40° for 1.5 hours
2. temperatureThe mixture is cooled to 20°-25°
3. customThe solids are isolated by filtration
4. washwashed with hexane/ethyl acetate (85/15, 13 ml)