反应详情

The procedure of Example 1 was essentially repeated, except that the xylenol was replaced with 540 g (5.0 moles) of orthocresol, and gaseous hexafluoroacetone, 83 g (0.5 mole) was added via a glass gas delivery tube reaching below the surface of the well-stirred mixture. At the completion of the reaction, as in Example 1, after recrystallization from hexane, white crystals of 1-methyl-4(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenol having 99.7% purity and melting at 89.5°-90.5° C. were isolated from the reaction mixture.

1. additionwas added via a glass gas delivery tube
2. customAt the completion of the reaction
3. customas in Example 1, after recrystallization from hexane, white crystals of 1-methyl-4(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenol having 99.7% purity
4. custommelting at 89.5°-90.5° C. were isolated from the reaction mixture