O-Cresol → HCID 15680424, compound

HRID 2198617Notes

Reaction equation

HRID 2198617 reaction equation
[C:1]1([OH:9])(C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]1[CH3:7].C1(C)C(O)=CC=CC=1.[F:18][C:19]([F:27])([F:26])[C:20]([C:22]([F:25])([F:24])[F:23])=[O:21]>>[CH3:7][C:2]1[CH:3]=[C:4]([C:20]([OH:21])([C:22]([F:25])([F:24])[F:23])[C:19]([F:27])([F:26])[F:18])[CH:5]=[CH:6][C:1]=1[OH:9]

Participants

4

Reactant 3

HCID 335O-CresolHCID 12695HexafluoroacetoneHCID 20473549HCID 20473549, compound

Product 1

HCID 15680424HCID 15680424, compound

Procedure

The procedure of Example 1 was essentially repeated, except that the xylenol was replaced with 540 g (5.0 moles) of orthocresol, and gaseous hexafluoroacetone, 83 g (0.5 mole) was added via a glass gas delivery tube reaching below the surface of the well-stirred mixture. At the completion of the reaction, as in Example 1, after recrystallization from hexane, white crystals of 1-methyl-4(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenol having 99.7% purity and melting at 89.5°-90.5° C. were isolated from the reaction mixture.

Workup

  1. additionwas added via a glass gas delivery tube
  2. customAt the completion of the reaction
  3. customas in Example 1, after recrystallization from hexane, white crystals of 1-methyl-4(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)phenol having 99.7% purity
  4. custommelting at 89.5°-90.5° C. were isolated from the reaction mixture

Sources & evidence

ORD record
ord-c8bd5e49bf024162afc6f3272b29c0a5
Source dataset
uspto-grants-1982_11
Patent number
US04358624

Reaction notes

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