Hydrazine hydrate (1:1) → HCID 70548183, compound

HRID 2198869Notes

Reaction equation

HRID 2198869 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH:5]([C:16](=O)[CH3:17])[CH:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:7](=O)[CH3:8])C.O.[NH2:21][NH2:22]>C(O)C>[CH3:1][O:3][C:4]([C:5]1[CH:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([CH3:8])=[N:21][NH:22][C:16]=1[CH3:17])=[O:19]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54152323HCID 54152323, compound

Product 1

HCID 70548183HCID 70548183, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

19 g (75 mmols) of 2-acetyl-4-oxo-3-phenyl-pentanoic acid ethyl ester were heated to the boil together with 3.75 g (75 mmols) of hydrazine hydrate in 100 ml of ethanol under nitrogen for 10 hours. The solvent was then distilled off in vacuo and the residue was recrystallised from isopropanol.

Workup

  1. distillationThe solvent was then distilled off in vacuo
  2. customthe residue was recrystallised from isopropanol

Sources & evidence

ORD record
ord-50c0483c435c43ca93078dee2c751a8d
Source dataset
uspto-grants-1982_11
Patent number
US04360520

Reaction notes

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