反应详情

Trans-4-n-propylcyclohexane carboxylic acid (23.8 g, 0.14 mole), was dissolved in 150 ml of dry ether and added dropwise with stirring into a suspension of 11.4 g (0.3 mole) of LiAlH4 in 300 ml of ether. After the addition the mixture was heated for 2 hours at reflux, and then the supernatant LiAlH4 was decomposed with water while being cooled. The reaction mixture was then poured onto 20% hydrochloric acid and stirred until the inorganic salts dissolved. The product of formula (31) was extracted with diethyl ether; the combined organic phases were washed with water, dried with MgSO4 and concentrated.

1. additionadded dropwise
2. additionAfter the addition the mixture
3. temperaturewas heated for 2 hours
4. temperatureat reflux
5. temperaturewhile being cooled
6. dissolutiondissolved
7. extractionThe product of formula (31) was extracted with diethyl ether
8. washthe combined organic phases were washed with water
9. dry with materialdried with MgSO4
10. concentrationconcentrated