Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 2199979Notes

Reaction equation

HRID 2199979 reaction equation
Cl[CH2:2][C:3]1[C:4]([CH3:9])=[N:5][O:6][C:7]=1[CH3:8].Cl[C:11]1[CH:31]=[CH:30][CH:29]=[C:28](C)[C:12]=1[CH2:13][N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24]([OH:26])=[O:25])[CH:21]=2)[C:16]([CH3:27])=[N:15]1>>[CH3:9][C:4]1[C:3]([CH2:2][N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24]([OH:26])=[O:25])[CH:21]=3)[C:16]([CH3:27])=[N:15]2)=[C:7]([CH3:8])[O:6][N:5]=1.[CH2:13]([N:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24]([OH:26])=[O:25])[CH:21]=2)[CH:16]=[CH:27]1)[C:12]1[CH:11]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 60152152HCID 60152152, compound

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 68184445HCID 68184445, compound

Procedure

The titled compound (16.5 mg) as a white solid was prepared from the compound [102-4] obtained in the process (4) of Example 102 (21.0 mg) and 4-(chloromethyl)-3,5-dimethylisoxazole according to the method of the process (5) of Example 102.

Sources & evidence

ORD record
ord-09afe95dede6482aa210a8ec3ec11451
Source dataset
uspto-grants-2016_06
Patent number
US09359350B2

Reaction notes

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