反应详情

Add cyclopropanecarbonyl chloride (1.42 g, 13.68 mmol) slowly to a solution of tert-butyl N-(4-bromo-2-pyridyl)carbamate (1.24 g, 4.6 mmol), Et3N (1.38 g, 13.68 mmol) in DCM (15 mL) at 0° C. After addition, stir the reaction at room temperature for 2 hrs. Pour the reaction mixture to water (50 mL), extract with EtOAc (15 mL×3), combine the organic layers and wash with brine (100 mL). Dry over anhydrous Na2SO4; concentrate under reduced pressure to give the crude product (1.55 g) which is used without further purification. MS: (M+1): 241.0

1. additionAfter addition
2. customthe reaction at room temperature for 2 hrs
3. extractionextract with EtOAc (15 mL×3)
4. washwash with brine (100 mL)
5. dry with materialDry over anhydrous Na2SO4
6. concentrationconcentrate under reduced pressure