4-Methylmorpholine → HCID 118119370, compound

To a stirred solution of (S)-8,8-dimethyl-6,10-dioxaspiro[4.5]decane-2-carboxylic acid (1.5 g, 7.0 mmol) and NMM (1.15 ml, 10.50 mmol) in acetonitrile (35 ml), isobutyl chloroformate (1 ml, 7.70 mmol) was added drop wise at −5 to −10° C. After 1 h, a solution of ethyl 6-aminospiro[2.5]oct-5-ene-5-carboxylate (3.42 g, 17.50 mmol) in acetonitrile (15 ml) was added and the reaction was allowed to stir at 0° C. to −5° C. for 1 h followed by stirring overnight at 25-30° C. Upon completion, the reaction mixture was quenched by addition of water (10 ml). Organic solvent was removed under reduced pressure and the residue was diluted with ethyl acetate (50 ml) and 10% sodium bicarbonate (25 ml). The organic mass was extracted using ethyl acetate (3×50 ml). Combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford a crude solid, which was purified by column chromatography over silica gel using ethyl acetate in hexane as eluents to obtain the title compound (1.55 g, 56.6%).

1. stirringby stirring overnight at 25-30° C
2. customUpon completion, the reaction mixture was quenched by addition of water (10 ml)
3. customOrganic solvent was removed under reduced pressure
4. additionthe residue was diluted with ethyl acetate (50 ml) and 10% sodium bicarbonate (25 ml)
5. extractionThe organic mass was extracted
6. dry with materialCombined organic layer was dried over sodium sulfate
7. concentrationconcentrated under reduced pressure
8. customto afford a crude solid, which
9. customwas purified by column chromatography over silica gel

ORD record

ord-e2e170ff28d748bd880be1f85f55157f

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09359367B2