HRID2200494

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

结构：N#Cc1ncc(N[C@H](C2CC2)C2(NC(=O)OCc3ccccc3)CC2)nc1Nc1cccc(-c2ncccn2)c1

HCID86685609

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1ncc(N[C@H](C2CC2)C2(NC(=O)OCc3ccccc3)CC2)nc1Nc1cccc(-c2ncccn2)c1

HCID86685611

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID784

Hydrogen peroxide

H2O2

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a mixture of (R)-benzyl-1-((5-cyano-6-(3-(pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate in methanol (2 ml) was added K2CO3 (excess) and H2O2 (50%, a few drops). After completion, it was concentrated to give (R)-benzyl-1-((5-carbamoyl-6-(3-(pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate.

WORKUP

后处理

concentrationAfter completion, it was concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67100b1529624a23880e8c71f7f94b6c
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09359308B2
来源说明: uspto-grants-2016_06

反应 SMILES

[CH2:1]([O:8][C:9](=[O:40])[NH:10][C:11]1([C@H:14]([NH:18][C:19]2[CH:24]=[N:23][C:22]([C:25]#[N:26])=[C:21]([NH:27][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]4[N:39]=[CH:38][CH:37]=[CH:36][N:35]=4)[CH:29]=3)[N:20]=2)[CH:15]2[CH2:17][CH2:16]2)[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])([O-])=[O:42].[K+].[K+]>CO.OO>[CH2:1]([O:8][C:9](=[O:40])[NH:10][C:11]1([C@H:14]([NH:18][C:19]2[CH:24]=[N:23][C:22]([C:25](=[O:42])[NH2:26])=[C:21]([NH:27][C:28]3[CH:33]=[CH:32][CH:31]=[C:30]([C:34]4[N:39]=[CH:38][CH:37]=[CH:36][N:35]=4)[CH:29]=3)[N:20]=2)[CH:15]2[CH2:17][CH2:16]2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1